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    The South African Pharmaceutical Exhibition (SAPHEX) is scheduled for March 5-6, 2025, at the Sandton Convention Centre in Johannesburg.

    SAPHEX stands as the premier event for professionals in South Africa's pharmaceutical manufacturing industry. The exhibition brings together key players, decision-makers, and suppliers, showcasing the latest innovations in APIs, excipients, packaging, and machinery. Attendees can expect to network, explore new advancements, and engage in discussions pivotal to the growth of the African pharmaceutical market.


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    Latest Medical Articles

    Unusual bleeding during and after pregnancy

    When should pregnant women be concerned? Awareness of the dangers associated with abnormal bleeding during pregnancy and after childbirth can be lifesaving for both women and their babies.

    Dr. Mzuvele Archwell Hlabisa, an obstetrician and gynaecologist at Netcare Kingsway Hospital, emphasizes that while many people are unaware that over a third of pregnant women may experience bleeding for various reasons, it is crucial to determine the exact cause.

    "Although some bleeding is normal in the postpartum period, excessive bleeding can be life-threatening. It is often difficult for women to discern if their bleeding is normal or not, but a good rule of thumb is to have any bleeding during pregnancy checked by a healthcare professional," says Dr. Hlabisa.

    He notes that around 35% of women experience bleeding in the first trimester. "As the pregnancy progresses, the likelihood of bleeding decreases, so it’s reassuring when women reach the mid-trimester, from 13 to 28 weeks of gestation."

    Bleeding could indicate a miscarriage or a threatened miscarriage, and severe pain with bleeding could be related to placental abruption, a serious condition where the placenta prematurely separates from the womb. These conditions require immediate medical assessment.

    Spotting In early pregnancy, some women may experience spotting, known as implantation bleeding, when the embryo implants in the uterine wall. ...Read full article

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    Global Medical News

    FDA Approves Suzetrigine: A Breakthrough Non-Opioid Painkiller
    The U.S. Food and Drug Administration (FDA) has approved suzetrigine, marking the first non-opioid painkiller approval in over two decades. This development is significant as medical professionals have been actively working to reduce opioid use, particularly in post-surgical pain management. Studies show that patients taking opioids for more than a week after surgery double their risk of long-term use, with around 6% of surgical patients in the U.S. becoming persistent opioid users—even if they had never taken opioids before.

    Suzetrigine offers a promising alternative by blocking sodium channels in nerve cells responsible for transmitting pain signals. Unlike traditional local anesthetics such as lidocaine, which affect sodium channels throughout the body—including those controlling heart, brain, and respiratory functions—suzetrigine is designed to target pain without these systemic risks.

    While the concept of using sodium channel blockers for pain relief is well established, previous efforts have been hindered by the widespread presence of these proteins in the body. Uncontrolled blockage poses serious risks, including potential fatal outcomes. However, the approval of suzetrigine represents a major step forward in providing effective pain relief without the dangers of opioid addiction or systemic anesthetic side effects.
    07 February 2025

    SAs Healthcare Crisis: Profmed Launches Platform to Connect Unempoyed Doctors with Opportunities
    South Africa is facing a perplexing healthcare crisis characterized by a shortage of medical professionals in certain regions while hundreds of qualified doctors remain unemployed. To tackle this issue, Profmed has introduced a new platform, www.finDR.doctor, aimed at connecting young doctors seeking employment with medical facilities in need of their skills.

    According to Profmed CEO Craig Comrie, this initiative is a critical intervention at a time when effective solutions are urgently required. The platform is designed not only to facilitate job opportunities but also to offer an incentive of six months of free Profmed medical aid to the first 100 unemployed graduate doctors under 30 who register on finDR.

    Comrie stated that finDR is a reflection of Profmed’s long-standing commitment to supporting the medical profession, a mission they have upheld since the 1960s. He emphasized that the platform addresses the employment gap among doctors while alleviating pressure on the healthcare system, ultimately making quality care more accessible across South Africa.

    In January 2025, the South African Medical Association (SAMA) raised concerns about over 1,800 qualified doctors who have completed their community service but are unable to find employment. The South African Medical Association Trade Union (SAMATU) echoed these concerns, noting that unemployed doctors have protested in Mpumalanga and Eastern Cape, demanding job opportunities amid the unemployment crisis.

    Dr. Cedric Sihlangu, the general secretary of SAMATU, pointed out that a significant challenge in the healthcare sector is the high number of unemployed doctors who have completed their community service. Despite extensive training and a pressing need for healthcare services in many areas, these professionals remain in a state of uncertainty.

    Health Minister Aaron Motsoaledi acknowledged the concerns raised by doctors and unions, recognizing the mounting pressure on the Department of Health to hire unemployed doctors. However, he noted that budget constraints limit new appointments and encouraged doctors to consider opportunities in the private sector and abroad.
    6 February 2025

    New Test Predicts Bowel Cancer Risk in IBD Patients with 90% Accuracy
    Individuals with inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, face a higher risk of developing colorectal cancer due to chronic inflammation, which can lead to abnormal cell growth (dysplasia) and precancerous polyps in the intestinal tract.

    To monitor this risk, patients with IBD typically undergo colorectal cancer screening via colonoscopy every one to three years. However, previous research indicates that identifying precancerous cells in these individuals can be challenging.

    Researchers from The Institute of Cancer Research in London have developed a new test that reportedly predicts bowel cancer risk in people with IBD with 90% accuracy, offering a potential breakthrough in early detection and prevention.
    05 February 2025

    FDA Approves JOURNAVXâ„¢, a New Non-Opioid Pain Medication
    The U.S. Food and Drug Administration (FDA) has approved JOURNAVXâ„¢ (suzetrigine), the first oral medication of its kind, for treating adults with moderate to severe acute pain. Developed by Vertex Pharmaceuticals, JOURNAVX represents a significant advancement in pain management by providing effective and well-tolerated relief without the risk of opioid addiction. Priced at $15.50 per 50 mg pill in the U.S., the medication has been approved for a twice-daily dosage regimen.

    Acute pain affects over 80 million Americans each year and is defined as lasting less than three months. Addressing this widespread issue with improved treatment options is essential to enhancing patient outcomes and reducing economic and societal burdens. JOURNAVX introduces an innovative, non-opioid solution, reflecting a broader shift toward safer and more effective pain management strategies. This breakthrough paves the way for further advancements in treating both acute and chronic pain without opioid dependence.

    JOURNAVX works by specifically targeting the NaV1.8 voltage-gated sodium channel, a crucial component in transmitting pain signals through nociceptors—neurons in the peripheral nervous system that detect pain. Unlike traditional painkillers that act on the central nervous system, JOURNAVX blocks these signals at the peripheral level, minimizing the risks associated with opioid use. This distinct mechanism makes it the first approved medication in a new class of non-opioid pain relievers.

    The FDA's approval follows rigorous evaluation in two randomized, double-blind clinical trials involving patients undergoing abdominoplasty and bunionectomy. Participants who received JOURNAVX experienced significantly greater pain reduction compared to those on a placebo, with ibuprofen available as a rescue medication for breakthrough pain.

    The safety profile of JOURNAVX was assessed using data from 874 participants in these trials, supported by a separate open-label study involving 256 patients with various acute pain conditions. The most commonly reported side effects included itching, muscle spasms, elevated creatine phosphokinase levels, and rash.
    04 February 2025

    Lion’s Mane Mushroom: A Rising Star in Health and Wellness
    Lion’s mane mushrooms are gaining recognition as a potential powerhouse supplement for overall well-being. Praised for their ability to enhance memory, sharpen focus, and even support neural regeneration, these fungi are drawing significant attention.

    While research is still in its early stages, initial findings are promising. According to Healthline, lion’s mane contains compounds called hericenones and erinacines, which may promote brain cell growth and help protect against cognitive decline. A 2020 human study found that individuals with mild Alzheimer’s who took lion’s mane for 49 weeks experienced improved cognitive function.

    Beyond brain health, lion’s mane may offer additional benefits. WebMD notes that these compounds could help alleviate anxiety and depression by supporting hippocampus function, a brain region critical for memory and emotion.

    The mushroom’s potential extends further, with supplement experts highlighting its anti-inflammatory and antioxidant properties, which may reduce oxidative stress—a key contributor to chronic diseases. Research also suggests it could support digestive health by preventing ulcers and inhibiting harmful bacteria. Additionally, studies indicate lion’s mane may aid nerve repair, offering potential hope for spinal cord injuries and neurodegenerative conditions.
    03 February 2025

    U.S. Funding Halt Forces Closure of South African HIV Clinics
    Engage Men's Health, a nonprofit organization in South Africa, has been providing free HIV testing and preventive medications at three clinics across the country. However, as of Monday, the organization has ceased operations following an order from the U.S. government to stop all activities immediately.

    The closure comes in response to a directive issued on Friday by the Trump administration, halting all global health funding, including support for the U.S. President's Emergency Plan for AIDS Relief (PEPFAR). Notices on the organization's website and social media confirm that the clinics will remain closed until further notice.
    31 January 2025
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