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Systemic lupus erythematosus

Information from the Medical Directory health library.

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This information supports, and does not replace, advice from your healthcare professional.

Overview

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease where the immune system attacks healthy tissues, affecting the skin, joints, kidneys, and other organs.

Symptoms

Fatigue and fever Joint pain, stiffness, and swelling Butterfly-shaped rash on the face Photosensitivity Kidney problems and fluid retention

Causes

Autoimmune reaction with unclear exact triggers Genetic predisposition Environmental triggers such as sunlight or infections Hormonal factors

Diagnosis

Blood tests for antinuclear antibodies (ANA) Complement levels and other autoimmune markers Urine tests for kidney involvement Clinical examination for characteristic symptoms

Treatment

Anti-inflammatory medications (NSAIDs) Corticosteroids for flare-ups Immunosuppressants for severe cases Hydroxychloroquine for skin and joint symptoms Regular monitoring of organ function

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