06 March 2025

Advances in Stem Cell Treatment for Unilateral Limbal Stem Cell Deficiency (LSCD)

Researchers estimate that over 10 million people worldwide suffer from corneal blindness due to disease or injury to the eye’s cornea. Unilateral limbal stem cell deficiency (LSCD), a condition caused by certain injuries, can result in severe vision loss. A new clinical trial is testing a promising stem cell treatment for LSCD, and preliminary results show that 50% of treated participants experienced full cornea restoration within three months.

The cornea, the transparent outer layer at the front of the eye, plays a crucial role in vision by contributing up to 75% of the eye’s focusing power. LSCD occurs when there is a shortage of limbal stem cells, which are responsible for regenerating the cornea. This condition can lead to symptoms like eye pain, blurred vision, and even permanent vision loss.

LSCD is typically caused by corneal injuries such as burns, chemical damage, or prolonged contact lens wear. Current treatment options for LSCD include surgical procedures like limbal stem cell transplants, corneal scraping, and amniotic membrane patching.